Stanford Scientists Discover “Natural Ozempic” That May Deliver Weight Loss Without Common Side Effects
Researchers at Stanford Medicine have identified a naturally occurring peptide that mimics the appetite-suppressing and weight-loss effects of Ozempic (semaglutide) while appearing to avoid many of its unpleasant side effects.
The molecule, named BRP (BRINP2-related peptide), significantly reduced food intake and promoted fat loss in animal studies without causing nausea, constipation, slowed digestion, or muscle loss — common complaints among users of GLP-1 medications.
A More Targeted Approach to Appetite Control
Unlike semaglutide, which activates receptors throughout the body (including the gut and pancreas), BRP appears to act more selectively in the hypothalamus — the brain region responsible for regulating hunger and metabolism.
"The receptors targeted by semaglutide ar...